The Telomere CDON
Telomeres and Telomerase in Cancer: Hiyama, Keiko: Amazon.se
 Se hela listan på en.wikipedia.org Telomerase activity, cell proliferation, and cancer Carol W. Greider* Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 617 Hunterian Building, 725 N. Wolfe Street, Baltimore, MD 21205 Telomerase and telomere length have received a lot of recent attention from the biomedical research community. The can- [Telomerase and cancer]. [Article in Japanese] Oshimura M(1). Author information: (1)Department of Molecular & Cell Genetics, School of Life Sciences, Tottori University.
While every cell in the body has the genetic coding to produce telomerase, only certain cells actually need it. Telomerase has been a prime target for the development of effective therapeutics against cancer as it is expressed in the majority of cancer types as well as in cancer stem or stem-like cells. In addition, normal human cells including stem cells have lower telomerase activity and generally maintain telomeres at longer lengths compared to cancer [Telomerase and cancer]. [Article in Japanese] Oshimura M(1). Author information: (1)Department of Molecular & Cell Genetics, School of Life Sciences, Tottori University. Telomeres progressively shorten with age in somatic cells in culture and in vivo because DNA replication results the loss of sequence at the 5' ends of double-stranded DNA. Thus, telomerase might be essential for the continued growth of immortal cells. If telomerase regulation in human tumors is similar to this cell-culture model, telomerase could be an important new target for anti-cancer therapy6,]4.
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In this model, telomerase activation occurs after the selection of mutations that stimulate abnormal cell proliferation, and, thus, telomerase activation may be a relatively late event in tumor initiation that allows for genome stability after the acquisition of cancer-associated mutations. It is believed that cancer occurs because a genetic mutation can trigger the production of an enzyme, known as telomerase, which prevents telomeres from shortening. While every cell in the body has the genetic coding to produce telomerase, only certain cells actually need it.
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2019-06-21 2020-05-31 A video overview of what telomerase is, its function in normal cells and how telomerase activating mutations can lead to cancer.By The Immortal Instruments: Telomerase, an enzyme responsible for the synthesis of telomeres, is activated in many cancer cells and is involved in the maintenance of telomeres. The activity of telomerase allows cancer cells to replicate and proliferate in an uncontrolled manner, to infiltrate tissue, and to metastasize to distant organs. Because these genes coding for telomerase turn off after birth, normal cells do not have this abundance of telomerase in them.This makes it easier for radioactive micro complexes to be used for diagnosing purposes, since these biomarkers will attach to where there is an abundance of telomerase, which is also the likely site of the cancer cells. 70%-90% of all cancers have lengthened telomeres 2017-10-05 Telomerase is commonly expressed in human cancer cells. Increased telomerase expression produces vulnerability of cancer cells, distinguishing them from normal cells in the body, although normal cells do also have some active telomerase.
Downregulation of telomerase activity in human promyelocytic cell line
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"Telomerase and Cancer Therapeutic" av Ahmed · Book (Bog). På engelsk. Releasedatum 17/9.
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Telomerase is an attractive target for diagnosis and therapy since it is expressed in over 90% of breast cancer cells, while it is not expressed in most normal cells. Whereas most of the progress on the role of telomerase in breast cancer has been in diagnostics, research into telomerase inhibitors is increasing. 2019-06-10 · Background Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to maintaining telomere length, TERT activates manifold cell survival signaling pathways.
Agents able to hobble telomerase might
In cancer, telomerase becomes active during telomere crisis and rescues the genomically abnormal cells by lengthening telomeres. In a series of experiments in a lymphoma mouse model, the team found: Telomerase reactivation in malignant cells after genomic instability causes cancer progression. However, cancer cell function as the opposite of that, this mutant genes have a high division rate and normally have longer TL and telomerase activity (Macieira-Coelho, 1994; Brinkley, 2001).
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Telomere-restriktionsfragmentanalys avslöjade långa och heterogena The use of telomerase inhibitors in cancer chemotherapy was dissuaded by a ”Mechanisms of Breast Cancer Risk in Shift Workers: Association of Telomere Shortening with the Duration and Intensity of Night Work”, Cancer Medicine 6, Telomerase is commonly expressed in human cancer cells. Increased telomerase expression produces vulnerability of cancer cells, distinguishing them from normal cells in the body, although normal cells do also have some active telomerase.
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Telomeres and Telomerase in Cancer: Hiyama, Keiko: Amazon.se
Telomerase activity can be found in most tumor cells, implicating that an active telomerase seems to be a prerequisite for tumor growth.
Telomeras – Wikipedia
However, telomerase-associated gene signatures in cancer remain elusive.
Until now, there are several good books on telomere and telomerase Telomeres and Telomerase in Cancer: Hiyama, Keiko: Amazon.se: Books. from basic biology and hypothesis in human normal cells and cancer cells to Pris: 2723 kr. inbunden, 2009. Skickas inom 2-5 vardagar.